Cardiovascular Disease
We study the mechanisms underlying major cardiovascular disorders, including heart failure, hypertension, and arrhythmias. Our work has identified novel molecular targets to treat these conditions, and we continue to lead innovative efforts aimed at improving cardiovascular outcomes.
Metabolic Disorders
The laboratory investigates the key mechanisms underlying diabetes mellitus, with a particular focus on pancreatic beta cell dysfunction, metabolic stress, and organ cross-talk contributing to disease progression.
Non-coding RNA
We investigate the functional contribution of non-coding RNAs, including microRNAs, to the pathophysiology of human disease. These molecules are studied both as biomarkers and as potential therapeutic targets across multiple disease contexts.
Calcium
The Santulli Lab investigates the functional roles of calcium signaling in health and disease across diverse tissues and cell types, with implications for cardiovascular, metabolic, and neuromuscular disorders.
Stem Cells
We investigate strategies to obtain mature human stem cells and apply stem-cell–based approaches to human disease. To this aim, we leverage state-of-the-art bioengineering and regenerative medicine technologies.
Translational Medicine
Fundamental discoveries generated in the laboratory are actively translated to the clinical setting, with the ultimate goal of improving diagnosis, treatment, and prevention of human disease.
Aging and Healthy Longevity
Our laboratory investigates the physiology and biology of aging, including the molecular mechanisms underlying senescence. We also study the roles of diet and nutrition in promoting healthy longevity.
Clinical Research
We conduct clinical research in the fields of cardiovascular medicine, diabetes, and aging. Please find here our clinical publications.
